Dimethylformamide → HCID 67790386, compound

Participants

Reaction Steps

A solution of 0.65 g of 1-ethoxycarbonyl-5,6-dihydro-4h-thieno[3,4-c]pyrrole hydrochloride and 1.47 ml of N,N-diisopropylethylamine in 15 ml of dimethylformamide is poured onto a mixture of 0.75 g of 2-chloromethyl-1H-4,5dihydroimidazole hydrochloride, 0.5 ml of N,N-diisopropylethylamine and 15 ml of dimethylformamide. The mixture is subjected to ultrasound for 4 h and is then evaporated under vacuum. The residue is dissolved in 3 ml of ethanol and chromatography is carried out on a silica column with ethanol as eluent. After evaporating the solvent, the residue is treated with 5 ml of isopropanol saturated with hydrochloric acid. 0.182 g of product is obtained. Melting point: 213°-215° C. (with decomposition).

Provenance & Evidence