Dimethylformamide → HCID 18947059, compound

Participants

Reaction Steps

0.53 g of 1-ethyl-5,6-dihydro-4H-thieno-[3,4-c]pyrrole hydrochloride, 1.47 ml of N,N-diisopropylethylamine and 15 ml of dimethylformamide are introduced into a 25 ml round-bottomed flask and then a solution of 0.75 g of 2-chloromethyl-1H-4,5-dihydroimidazole hydrochloride and 0.5 ml of N,N-diisopropylethyl-amine in 15 ml of dimethylformamide is added. The reaction mixture is subjected to ultrasound for 8 h, the solvent is then evaporated and the residue is purified by chromatography on silica gel with ethanol as eluent. The product is recrystallized from 5 ml of isopropanol saturated with hydrochloric acid. 0.233 g of product is obtained. Melting point: 207°-208° C. (with decomposition).

Provenance & Evidence