HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Benzeneacetyl chloride, 4-bromo-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Benzeneacetic acid, 4-bromo- | HCID 74654 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Benzeneacetyl chloride, 4-bromo- | HCID 181552 | — |
Reaction Steps
Initially, oxalyl chloride is added to an equimolar amount of p-bromophenylacetic acid (13) in an inert solvent, preferably methylene chloride, at about room temperature, with a catalytic amount of dimethylformamide. The mixture is stirred for about 30 minutes, after which the product, p-bromophenylacetyl chloride (14), is isolated by conventional means.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05380739 |
| Source dataset | uspto-grants-1995_01 |
| ORD ID | ord-95273adc01814d45aef64aa4dc3ed6d9 |
| Source note | uspto-grants-1995_01 |