反应详情

A mixture of 2-(4-methylphenyl)-3-cyanothiophene (1.5 g, 7.5 mmol), N-bromosuccinimide (1.34 g, 7.5 mmol), and azabicyclononane (20 mg) in carbon tetrachloride was irradiated with UV light for one hour. The reaction mixture was cooled, and the solid filtered off. The filtrate was concentrated, and the residue purified by flash chromatography, eluting with 5% ethyl acetate/hexane, to yield 2-(4-bromomethylphenyl)-3-cyanothiophene 1.4 g, m.p. 68-75 (slightly impure, used as such).

1. customwas irradiated with UV light for one hour
2. temperatureThe reaction mixture was cooled
3. filtrationthe solid filtered off
4. concentrationThe filtrate was concentrated
5. customthe residue purified by flash chromatography
6. washeluting with 5% ethyl acetate/hexane