HCID 56993354, compound → HCID 57120211, compound

Participants

Reaction Steps

To a solution of 1-(3-methoxycarbonyl-2-nitrophenyl)butan-2-one ethylene ketal (36) (1.12 g) (prepared, e.g., as described in Preparation 24), in absolute ethanol (50 ml) was added palladium on carbon (150 mg, 10%), and the mixture stirred under hydrogen at atmospheric pressure and room temperature for 6 hours. The reaction mixture was passed through a Celite pad to remove catalyst, and the pad was washed with methylene chloride. The combined filtrate and washings were concentrated under reduced pressure to give 1-(2-amino-3-methoxycarbonyl-phenyl)butan-2-one ethylene ketal (0.98 g), a compound of Formula (37), as a colorless oil.

Provenance & Evidence