反应详情

50 ml of a dry diethyl ether solution containing 20 g of 1,6-anhydro-3,4-dideoxy-β-D-glycero-hex-3-enopyranos-2-ulose, was gradually dropwise added to 500 ml of a dry diethyl ether suspension containing 3.0 g of lithium aluminum hydride, at 0° C. under an inert atmosphere of nitrogen gas. After completion of the dropwise addition, the mixture was immediately returned to room temperature, and stirring was continued for 30 minutes. Disappearance of the starting material was confirmed by thin layer chromatography, and then a small amount of water was added to inactivate an excess amount of lithium aluminum hydride. The mixture was further stirred for 30 minutes, and the reaction mixture was filtered through Celite® to remove the precipitate. The precipitate was washed a few times with diethyl ether, and the washing solutions were concentrated under reduced pressure together with the filtrate. Precipitated crude crystals were recrystallized from diethyl ether to obtain 14.5 g of the desired product (Compound No. 1). The NMR analytical data and physical properties of this product were as follows.

1. customat 0° C.
2. additionAfter completion of the dropwise addition
3. customwas immediately returned to room temperature
4. stirringThe mixture was further stirred for 30 minutes
5. filtrationthe reaction mixture was filtered through Celite®
6. customto remove the precipitate
7. washThe precipitate was washed a few times with diethyl ether
8. concentrationthe washing solutions were concentrated under reduced pressure together with the filtrate
9. customPrecipitated crude crystals
10. customwere recrystallized from diethyl ether