Nitric Acid → HCID 178526854, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(2,6-dichloro-4-trifluoromethylphenyl)-imidazole (5.62 g, 0.02 mol), nitric acid (70% w/w, 5.6 ml) and sulphuric acid (98% w/w, 5.6 ml) was strirred and heated at 70° C. for a total of 51 hours. After cooling the ceaction mixture was poured into a mixture of ice and water (approximately 75 ml) and the precipitated solid was filtered off. It was purified by mplc on silica eluted with a mixture of ethyl acetate and dichloromethane (1:20) to give 2-(2,6-dichloro-4-trifluoromethylphenyl)-4-nitroimidazole (4.21g), m.p. 254°-255° C., as a cream crystalline solid.

Provenance & Evidence