L-Lysine monohydrochloride → L-Lysine

HRID 1769304Notes

Reaction equation

HRID 1769304 reaction equation
Cl.[NH2:2][C@H:3]([C:9]([OH:11])=[O:10])[CH2:4][CH2:5][CH2:6][CH2:7][NH2:8]>O>[NH2:2][C@H:3]([C:9]([OH:11])=[O:10])[CH2:4][CH2:5][CH2:6][CH2:7][NH2:8]

Participants

3

Reactant 1

HCID 69568L-Lysine monohydrochloride

Product 1

HCID 5962L-Lysine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A solution of L-lysine hydrochloride (0.36973 mole, 67.532 g) in water (68 g) [from stream 36a in Example 9 and stream 36b in Example 11] is added to the top of a column of Amberlyte IRA-400(OH) ion exchange resin (254.54 g, 0.4073 equivalents) prewashed with water. The column is subsequently eluted with water (742 g) to provide an aqueous solution of free L-lysine from which water is partially evaporated at 60° C. and 20 mm HgA pressure. The resulting evaporation residue [stream 5a] contains free L-lysine (0.36973 moles, 54.05 g) and water (54 g) for recycle to first crop crystallization (Example 2).

Workup

  1. washThe column is subsequently eluted with water (742 g)

Sources & evidence

ORD record
ord-bd3a69f64d3f4bfcab1807dad4714993
Source dataset
uspto-grants-1995_01
Patent number
US05380867

Reaction notes

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