HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Chloride → 3-[N-Benzyl-3-(4-chlorobenzyl)-6-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Chloride | HCID 7503 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Methyl 3-[N-(phenylsulfonyl)-3-(4-chlorobenzyl)-6-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoate | HCID 18947579 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-[N-Benzyl-3-(4-chlorobenzyl)-6-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid | HCID 18947596 | — |
Reaction Steps
The title compound was prepared under the conditions described in Step A and Step B of Example 38, but substituting benzyl chloride for the benzenesulfonyl chloride from Example 38 (Step A). Anal. C, H, N for sodium salt 1/2 H2O Calc. C 71.66; H 5.36; N 4.52 Found. C 71.65; H 5.49; N 4.44.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05380850 |
| Source dataset | uspto-grants-1995_01 |
| ORD ID | ord-a9d37e24856649b9bd9c96b394bfa993 |
| Source note | uspto-grants-1995_01 |