HuagongsheHuagongshe Chemistry Print Report · For research reference only
Allyl bromide → 3-[N-Allyl-3-(4-chlorobenzyl)-6-(quinolin-2-ylmethoxy)-indol-2-yl]-2,2-dimethylpropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Allyl bromide | HCID 7841 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Methyl 3-[N-(phenylsulfonyl)-3-(4-chlorobenzyl)-6-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoate | HCID 18947579 | — |
| Product | 3-[N-Allyl-3-(4-chlorobenzyl)-6-(quinolin-2-ylmethoxy)-indol-2-yl]-2,2-dimethylpropanoic acid | HCID 18947555 | — |
Reaction Steps
The title compound was prepared under the conditions described in Step A and Step B of Example 38, but substituting allyl bromide for the benzenesulfonyl chloride from Example 38 (Step A). Anal. C, H, N for sodium salt·2 H2O Calc. C 66.38; H 5.74; N 4.69 Found C 66.57; H 5.75; N 4.73.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05380850 |
| Source dataset | uspto-grants-1995_01 |
| ORD ID | ord-e20d76f2bbc747f0b41e6ecc7166f135 |
| Source note | uspto-grants-1995_01 |