Water → HCID 86748394, compound

Participants

Reaction Steps

A solution of methyl (E)-6-(1,3-dihydro-4-amino-6-methoxy-7-methyl-3- oxoisobenzofuran-5-yl)-4-methyl-4-hexenoate (0.32g, 1 mmol) in 3ml formic acid was cooled to 0° C. and treated with 0.45g of carbonyldiimidazole. After 1 hour water was added and the precipitate collected by filtration. This material was recrystallized from isopropanol to give 0.24g of methyl (E)-6-[1,3-dihydro-4-formamido-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl]-4-methyl-4-hexenoate, as a white solid, mp 187°-189° C.

Provenance & Evidence