反应详情

温度

100 °C

A mixture of L-leucyl-L-tryptophan benzyl ester (408 mg) and 3-(1-naphthyl)propionaldehyde (220 mg) in toluene (10 ml) was heated to reflux in a Dean-Stark apparatus for 2 hours. After cooling, dibenzyl phosphite (252 mg) and acetonitrile (10 ml) were added to the mixture and the resulting solution was stirred at 100° C. for 16 hours. After being cooled to room temperature, the mixture was concentrated under reduced pressure. The residue was separated and purified by silica gel chromatography (chloroform:ethyl acetate=5:1) to give two diastereomers of the title compound as colorless oil (a: 58 mg, b: 95 mg).

1. temperaturewas heated
2. temperatureto reflux in a Dean-Stark apparatus for 2 hours
3. temperatureAfter cooling
4. temperatureAfter being cooled to room temperature
5. concentrationthe mixture was concentrated under reduced pressure
6. customThe residue was separated
7. custompurified by silica gel chromatography (chloroform:ethyl acetate=5:1)