HCID 18658480, compound → HCID 18658481, compound

HRID 1769441Notes

Reaction equation

HRID 1769441 reaction equation
C([O:8][C:9](=[O:33])[C@H:10]([CH2:29][CH:30]([CH3:32])[CH3:31])[NH:11][C@H:12]([P:21]([O:26][CH2:27][CH3:28])([O:23][CH2:24][CH3:25])=[O:22])[CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)C1C=CC=CC=1.[H][H]>C(O)C>[CH2:27]([O:26][P:21]([C@@H:12]([NH:11][C@H:10]([C:9]([OH:33])=[O:8])[CH2:29][CH:30]([CH3:31])[CH3:32])[CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)([O:23][CH2:24][CH3:25])=[O:22])[CH3:28]

Participants

4

Reactant 2

HCID 18658480HCID 18658480, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18658481HCID 18658481, compoundYield 101.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 230 mg of N-[1-(R)-diethoxyphosphoryl-3-phenylpropyl]-L-leucine benzyl ester in 5 ml of 95% ethanol was added 50 mg of 10% Pd--C, and the mixture was stirred under an atmospheric pressure of hydrogen at room temperature for 3 hours. The Pd--C was filtered off, and the solvent was distilled off under reduced pressure to yield the title compound as a colorless oil (190 mg).

Workup

  1. filtrationThe Pd--C was filtered off
  2. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-9babc91662d947a8bc3bbd970fabb9c9
Source dataset
uspto-grants-1995_01
Patent number
US05380921

Reaction notes

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