Methanol → 2,4-Dichloro-6-methoxypyrimidine

HRID 1769485노트

반응식

HRID 1769485 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([Cl:9])[N:3]=1.CO.N1C(C)=CC(C)=CC=1C.C[CH2:22][O:23]CC>O1CCCC1>[CH3:22][O:23][C:6]1[N:7]=[C:2]([Cl:1])[N:3]=[C:4]([Cl:9])[CH:5]=1

참가 물질

6

반응물 4

HCID 887MethanolHCID 3283Diethyl EtherHCID 79532,4,6-TrimethylpyridineHCID 773782,4,6-Trichloropyrimidine

생성물 1

HCID 38245092,4-Dichloro-6-methoxypyrimidine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 2,4,6-trichloropyrimidine (55 g), methanol (50 ml) and collidine (50 g) is heated in dry tetrahydrofuran (400 ml) for 48 hr. Ether is added and the precipitate is collected. The precipitate is column chromatographed on silica gel to give 6-methoxy-2,4-dichloropyrimidine. This product is mixed with morpholine in THF and stirred at 20°-25° to give 6-methoxy-2-morpholino-4-chloropyrimidine. The 6-methoxy-2-morpholino-4-chloropyrimidine is heated with piperazine in pyridine at 60° for 24 hr to give the title compound.

후처리

  1. customthe precipitate is collected
  2. customchromatographed on silica gel

출처 및 근거

ORD 기록
ord-dbf7d922d0204806a72b1e5b0ceca092
출처 데이터셋
uspto-grants-1995_01
특허 번호
US05380840

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