4-Bromophenol → HCID 54531626, compound

Participants

Reaction Steps

A reaction vessel was charged with 10 g of p-bromophenol, 19 g of (S)-1-methylhexyl tosylate, 10 g of potassium carbonate and 150 ml of cyclohexanone, and the mixture was stirred under reflux for 15 hours (the starting materials were confirmed to have disappeared by GLC). The reaction liquid was filtered and the filter cake was washed with benzen. The washings and the filtrate were combined, washed with water and then dried over Glauber's salt. The solvents were distilled off and the residue was purified by way of column chromatography on silica gel (eluent:hexane) to obtain 14 g (89.4%) of (R)-4-(1-methylhexyl)oxybromobenzene.

Provenance & Evidence