Hydrochloric Acid → HCID 19379480, compound

Participants

Reaction Steps

A reaction vessel was charged with 12 g of 4-hydroxy-2'-fluoro-4'-bromobiphenyl obtained in Example 4(b), 14.2 g of decyl bromide, 15.7 g of potassium carbonate and 100 ml of 2-butanone (MEK), and the mixture was refluxed with stirring for 12 hours (the disappearance of the starting materials were confirmed by TLC). The reaction liquid was poured into diluted hydrochloric acid and the mixture was extracted with benzene. The extract was washed with water and dried over Glauber's salt. The solvents were distilled off and the residue was purified by way of column chromatography on silica gel (eluent:hexane) and then recrystallized from hexane to obtain 14.9 g (81.5%) of 4-decyloxy-2'-fluoro-4'-bromobiphenyl.

Provenance & Evidence