反应详情

Formic acid (82.7 g) and toluene (20 ml) were added to 1,1-ethylenedioxy-4-(3',4', 5'-trifluorophenyl)cyclohexane (95.02 g), followed by heating the mixture under reflux with stirring for 2 hours, adding the reaction solution to water (500 ml), extracting with ethyl acetate (1 l), drying the organic layer over anhydrous magnesium sulfate, distilling off the solvent under reduced pressure, and recrystallizing from ethanol, to obtain 4-(3',4',5'-trifluorophenyl)cyclohexanone (63.1 g). m.p. 123.5° C.

1. temperatureby heating the mixture
2. temperatureunder reflux
3. extractionextracting with ethyl acetate (1 l)
4. dry with materialdrying the organic layer over anhydrous magnesium sulfate
5. distillationdistilling off the solvent under reduced pressure
6. customrecrystallizing from ethanol