Formic Acid → HCID 19039176, compound

HRID 1769577Notes

Reaction equation

HRID 1769577 reaction equation
C(O)=O.C1(C)C=CC=CC=1.C1CO[C:13]2([CH2:18][CH2:17][CH:16]([C:19]3[CH:24]=[C:23]([F:25])[C:22]([C:26]([F:29])([F:28])[F:27])=[C:21]([F:30])[CH:20]=3)[CH2:15][CH2:14]2)[O:12]1>O>[F:25][C:23]1[CH:24]=[C:19]([CH:16]2[CH2:17][CH2:18][C:13](=[O:12])[CH2:14][CH2:15]2)[CH:20]=[C:21]([F:30])[C:22]=1[C:26]([F:28])([F:29])[F:27]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 1140TolueneHCID 86748402HCID 86748402, compound

Product 1

HCID 19039176HCID 19039176, compoundYield 88.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Formic acid (11.3 g) and toluene (5 ml) were added to 1,1-ethylenedioxy-4-(3',5'-difluoro-4'-trifluoromethylphenyl)cyclohexane (15.7 g), followed by heating the mixture under reflux with stirring for 2 hours, adding the reaction solution to water (50 ml), extracting with ethyl acetate (100 ml), drying the organic layer over anhydrous MgSO4, and distilling off the solvent under reduced pressure, to obtain 4-(3',5'-difluoro-4'-trifluoromethylphenyl)cyclohexanone (12.0 g).

Workup

  1. temperatureby heating the mixture
  2. temperatureunder reflux
  3. extractionextracting with ethyl acetate (100 ml)
  4. dry with materialdrying the organic layer over anhydrous MgSO4
  5. distillationdistilling off the solvent under reduced pressure

Sources & evidence

ORD record
ord-38a145f47ce14c66b584116d638d8668
Source dataset
uspto-grants-1995_01
Patent number
US05382379

Reaction notes

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