Nitrogen → 3-(3-Amino-1,2,4-oxadiazol-5-yl)-1-azabicyclo(2.2.1)heptane

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Reaction Steps

First, 10.31 g (57.53 mmol) of 4-Dimethylaminobenzhydrazide and then 100 ml of dehydrated pyridine are put in a three neck flask (capacity: 500 ml). Next, a cooling tube is attached to the mouth of the flask and N2 gas is installed inside. 4-Dimethylaminobenzhydrazide was dissolved in the pyridine by mixing at a room temperature. Further, 6.26 g (30.83 mmol) of Isophthaloyl Chloride was added to the system of reaction from a side tube of the three neck flask, and for 8 hours the pyridine was refluxed. After the reaction is done, pyridine is removed from the system of reaction by distillation. The reactant is washed well and is vacuum dried in a vacuum desiccator. Consequently an oxadiazole precursor is formed. The above reaction is expressed by the chemical formula 19 below. ##STR13## 2. The synthesis of an oxadiazole compound.

Provenance & Evidence