HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propionic anhydride → [3-[Di(propanoyloxy)methyl]-1-methyl-2-oxo-4-quinolyl] propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propionic anhydride | HCID 31263 | — |
| Reactant | 1-methyl-3-formyl-4-hydroxy-2(1H)-quinolinone | HCID 135454235 | — |
| Product | [3-[Di(propanoyloxy)methyl]-1-methyl-2-oxo-4-quinolyl] propanoate | HCID 5274968 | — |
Reaction Steps
Following the procedure of Example 5, 1-methyl-3-formyl-4-hydroxy-2(1H)-quinolinone (from Preparation B) was acylated with propanoic anhydride to give 1-methyl-3-[di-(1-oxopropoxy)]methyl-4-(1-oxopropoxy)-2(1H)-quinolinone. That the expected product was obtained was confirmed by the spectral data: MS (CI): m/e 390 (M.+ +1); NMR (CDCl3): δ1.14 (t, 6H, 2 x CH3CH2), 1.38 (t, 3H, CH3CH2), 2.39 (m, 4H, 2 x CH2CO), 2.83 (q, 2H, CH3CH2CO), 3.74 (s, 3H, NCH3), 8.10 (s, 1 H, (CH3CH2COO)2CH) ppm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05382572 |
| Source dataset | uspto-grants-1995_01 |
| ORD ID | ord-22d5b8e6c0304416bff960af5a72682e |
| Source note | uspto-grants-1995_01 |