Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | HCID 20097208 | HCID 20097208 | — |
| Solvent | 2-Methoxyethanol | HCID 8019 | — |
| Product | HCID 20097216 | HCID 20097216 | — |
Reaction Steps
Dissolve the 3-chloro-1-(pyrid-2-yl)-indole in 1500 cm3 of 2-methoxyethanol and heat to 100° C. with stirring. Add 1100 cm3 of 70% phosphoric acid in a fine stream. Continue heating for 6 hours and then treat the reaction mixture with charcoal under reflux for 15 mins. Filter. Heat to 70° C. while adding 2000 cm3 of water. Cool the precipitated product for 12 hours at 5° C. Filter and dry.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05382593 |
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| Source dataset | uspto-grants-1995_01 |
|---|
| ORD ID | ord-ee7fa3cd0aa244bd803d717aca3bd80c |
|---|
| Source note | uspto-grants-1995_01 |
|---|
