Hydrogen Bromide → (6S)-6-(Propylamino)-5,6,7,8-tetrahydronaphthalen-1-ol--hydrogen bromide (1/1)

Participants

Reaction Steps

A mixture of (S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-2-naphthalenamine (10.0 g, 0.0391 mol) as the HCl salt, or its corresponding free base, was heated at reflux in 48% hydrobromic acid (150 mL) for a period of two to three hours. The solution was cooled to room temperature and the resulting solid was collected by filtration. Drying under high vacuum at 60° C. gave 10.7 g of the product (96% yield).

Provenance & Evidence