Acetone → N-methyl-N-(2-(3,4-dimethoxyphenyl)ethyl)-N'-isopropyl-1,3-propanediamine

HRID 1769662Notes

Reaction equation

HRID 1769662 reaction equation
[CH3:1][N:2]([CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([O:17][CH3:18])[CH:10]=1)[CH2:3][CH2:4][CH2:5][NH2:6].[CH3:19][C:20]([CH3:22])=O>[Pt]=O.C(O)C>[CH3:1][N:2]([CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([O:17][CH3:18])[CH:10]=1)[CH2:3][CH2:4][CH2:5][NH:6][CH:20]([CH3:22])[CH3:19]

Participants

5

Reactant 2

HCID 180AcetoneHCID 104449491,3-Propanediamine, N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methyl-

Product 1

HCID 15023495N-methyl-N-(2-(3,4-dimethoxyphenyl)ethyl)-N'-isopropyl-1,3-propanediamineYield 100%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

3.87 g of N-methyl-N-(2-(3,4-dimethoxyphenyl)ethyl)-1,3-propanediamine and 15 ml of acetone were dissolved into 50 ml of ethanol. To this was added 0.1 g of platinum oxide and then hydrogenation was made at room temperature and under pressure of 3 kg/cm2. At the end of 3 hours catalyst was concentrated after filtering and 4.52 g of marked compound was obtained as yellow oily matter (yield: 100%.

Workup

  1. customwas made at room temperature and under pressure of 3 kg/cm2
  2. concentrationAt the end of 3 hours catalyst was concentrated
  3. filtrationafter filtering

Sources & evidence

ORD record
ord-0dd3b2d66fef416db2e837de1db5ab45
Source dataset
uspto-grants-1995_01
Patent number
US05382595

Reaction notes

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