Dimethylformamide → HCID 53854495, compound

Participants

Reaction Steps

A mixture of N-formylpiperazine (0.41 mL, 4.0 mmol), (4-nitro-2,6-dichlorophenyl)-2-bromoacetamide (1.31 g, 4.0 mmol), and K2CO3 (2.2 g) in 20 mL of DMF was stirred at room temperature for 15 minutes. The mixture was then partitioned between ethyl acetate and water, the aqueous extracts were diluted with brine, and then exhaustively extracted with ethyl acetate. Solvent was removed in vacuo from the combined ethyl acetate extracts to yield the III product as a residue (1.79 g): 1H NMR (300 MHz, CDCl3) δ 2.73-2.78 (m, 2H), 2.85-2.97 (m, 4H), 3.34 (s, 2H), 3.51-3.56 (m, 1H), 3.68-3.72 (m, 1H), 8.30 (s, 2H), 9.14 (broad s, 1H).

Provenance & Evidence