Triethylamine → Ethyl 1,4-dibenzylpiperazine-2-carboxylate

Participants

Reaction Conditions

Reaction Steps

To a solution of 1 (N,N'-dibenzylethylenediamine, 76.8 g, 0.296 mol) in toluene (240 mL) at 40° C. with mechanical stirring was added dropwise a solution of 2 (ethyl 2,3-dibromopropionate, 71.0 g, 0.296 mol) and triethylamine (84 mL, 0.60 mol) in 75 mL of toluene such that the temperature remained below 80° C. The mixture was stirred at 80° C. for 2.5 hours, then cooled. The resulting mixture was filtered, and the filtrate partitioned with 200 mL of water. The organic extract was dried with Na2SO4, and solvent removed in vacuo to yield an amber oil (3, 105 g, 100% yield). This material was used as is in the subsequent step, thus analysis was not obtained.

Provenance & Evidence