m-Tolyl isocyanate → HCID 14996848, compound

Participants

Reaction Steps

The procedure is analogous to that described in Example 1, but 2.2 g of 2-(2-amino-N-phenylacetamido)-N-(4-chlorophenyl)-N-methylacetamide and 0.87 g of 3-methylphenyl isocyanate are used as the starting material. The product obtained is purified by chromatography on 60 g of silica (0.065-0.200 mm) contained in a column 2.5 cm in diameter [eluent: methylene chloride/methanol (99-1 by volume)], collecting 20 cm3 fractions. Fractions 30 to 43 are combined and concentrated to dryness under reduced pressure (2.7 kPa) at 40° C. After recrystallization from acetonitrile, 1.0 g of N-(4-chlorophenyl)-N-methyl-2-{2-[3-(3-methylphenyl)ureido]-N-phenylacetamido}acetamide melting at 160° C. is obtained.

Provenance & Evidence