m-Tolyl isocyanate → HCID 14996863, compound

Participants

Reaction Steps

The procedure is analogous to that described in Example 1, but 1.45 g of (RS)-2-amino-N-[2-(2-methylpiperidino)-2-oxoethyl]-N-phenylacetamide and 0.67 g of 3-methylphenyl isocyanate used as the starting material. After recrystallization from a mixture of ethanol and diisopropyl ether (50-50 by volume), 0.80 g of (RS)-N-[2-(2-methylpiperidino)-2-oxoethyl]-2-[3-(3-methylphenyl)ureido]-N-phenylacetamide melting at 188° C. is obtained.

Provenance & Evidence