m-Tolyl isocyanate → HCID 14996878, compound

HRID 1769696Notes

Reaction equation

HRID 1769696 reaction equation
[NH2:1][CH2:2][C:3]([N:5]([CH2:12][C:13]([NH:15][CH2:16][CH:17]1[CH2:19][CH2:18]1)=[O:14])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].[CH3:20][C:21]1[CH:22]=[C:23]([N:27]=[C:28]=[O:29])[CH:24]=[CH:25][CH:26]=1>>[CH:17]1([CH2:16][NH:15][C:13](=[O:14])[CH2:12][N:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:3](=[O:4])[CH2:2][NH:1][C:28]([NH:27][C:23]2[CH:24]=[CH:25][CH:26]=[C:21]([CH3:20])[CH:22]=2)=[O:29])[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 69303m-Tolyl isocyanateHCID 14996877HCID 14996877, compound

Product 1

HCID 14996878HCID 14996878, compoundYield 75%

Procedure

The procedure is analogous to that described in Example 1, but 0.9 g of 2-(2-amino-N-phenylacetamido)-N-cyclopropylmethylacetamide and 0.45 g of 3-methylphenyl isocyanate are used as the starting material. After recrystallization from acetonitrile, 1 g of N-cyclopropylmethyl-2-{2-[3-(3-methylphenyl)ureido]-N-phenylacetamido}acetamide melting at 168° C. is obtained.

Workup

  1. customAfter recrystallization from acetonitrile

Sources & evidence

ORD record
ord-22b4c8aacdcc46c2b56f454fbe6f7f09
Source dataset
uspto-grants-1995_01
Patent number
US05382590

Reaction notes

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