m-Tolyl isocyanate → HCID 14996884, compound

HRID 1769698Notes

Reaction equation

HRID 1769698 reaction equation
[NH2:1][CH2:2][C:3]([N:5]([CH2:12][C:13]([NH:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:14])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].[CH3:23][C:24]1[CH:25]=[C:26]([N:30]=[C:31]=[O:32])[CH:27]=[CH:28][CH:29]=1>>[CH2:16]([NH:15][C:13](=[O:14])[CH2:12][N:5]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3](=[O:4])[CH2:2][NH:1][C:31]([NH:30][C:26]1[CH:27]=[CH:28][CH:29]=[C:24]([CH3:23])[CH:25]=1)=[O:32])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 69303m-Tolyl isocyanateHCID 14996883HCID 14996883, compound

Product 1

HCID 14996884HCID 14996884, compoundYield 47.8%

Procedure

The procedure is analogous to that described in Example 1, but 0.25 g of 2-(2-amino-N-phenylacetamido)-N-benzylacetamide and 0.11 g of 3-methylphenyl isocyanate are used as the starting material. After recrystallization from acetonitrile, 0.17 g of N-benzyl-2-{2-[3-(3-methylphenyl)ureido]-N-phenylacetamido]acetamide melting at 204° C. is obtained.

Workup

  1. customAfter recrystallization from acetonitrile

Sources & evidence

ORD record
ord-b7887903fd0f4ece8e65a1d620f7d1de
Source dataset
uspto-grants-1995_01
Patent number
US05382590

Reaction notes

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