m-Tolyl isocyanate → HCID 14996893, compound

HRID 1769699Notes

Reaction equation

HRID 1769699 reaction equation
[NH2:1][CH2:2][C:3]([N:5]([CH2:12][C:13]([NH:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[CH2:21][CH2:20][CH2:19]2)=[O:14])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].[CH3:25][C:26]1[CH:27]=[C:28]([N:32]=[C:33]=[O:34])[CH:29]=[CH:30][CH:31]=1>>[CH2:21]1[C:22]2[C:18](=[CH:17][C:16]([NH:15][C:13](=[O:14])[CH2:12][N:5]([C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:3](=[O:4])[CH2:2][NH:1][C:33]([NH:32][C:28]3[CH:29]=[CH:30][CH:31]=[C:26]([CH3:25])[CH:27]=3)=[O:34])=[CH:24][CH:23]=2)[CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 69303m-Tolyl isocyanateHCID 14996892HCID 14996892, compound

Product 1

HCID 14996893HCID 14996893, compoundYield 19.4%

Procedure

The procedure is analogous to that described in Example 1, but 3.0 g of 2-(2-amino-N-phenylacetamido)-N-(5-indanyl)acetamide and 1.2 g of 3-methylphenyl isocyanate are used as the starting material. After recrystallization from acetonitrile, 0.8 g of N-(5-indanyl)-2-{2-[3-(3-methylphenyl)ureido]-N-phenylacetamido}acetamide melting at 210° C. is obtained.

Workup

  1. customAfter recrystallization from acetonitrile

Sources & evidence

ORD record
ord-21f3fb68a7d440ed9e41d2b80b65f9d3
Source dataset
uspto-grants-1995_01
Patent number
US05382590

Reaction notes

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