Hydrazine hydrate (1:1) → HCID 14996905, compound

Participants

Reaction Steps

The procedure is analogous to that described in Example 23, but 2.7 g of N-methyl-N-(3-methylphenyl)-2-(N-phenyl-2-phthalimidoacetamido)acetamide, 0.6 g of hydrazine hydrate and 0.8 g of 3-methylphenyl isocyanate are used as the starting material. The product obtained is purified by chromatography on 25 g of silica gel (0.065-0.200 mm) contained in a column 1.7 cm in diameter [eluent: methylene chloride/ethyl acetate (80-20 by volume)], collecting 25 cm3 fractions. Fractions 13 to 27 are combined and concentrated to dryness under reduced pressure (2.7 kPa) at 40° C. After recrystallization from diethyl ether, 0.86 g of N-methyl-N-(3-methylphenyl)-2-{2-[3-(3-methylphenyl)ureido]-N-phenylacetamido}acetamide melting at 165° C. is obtained.

Provenance & Evidence