Hydrazine hydrate (1:1) → HCID 14996937, compound

Participants

Reaction Steps

The procedure is analogous to that described in Example 23, but 1.2 g of N-(4-methoxyphenyl)-2-(N-phenyl-2-phthalimidoacetamido)acetamide, 0.28 g of hydrazine hydrate and 0.38 g of 3-methylphenyl isocyanate are used as the starting material. The product obtained is purified by chromatography on 25 g of silica (0.065-0.200 mm) contained in a column 1.7 cm in diameter [eluent: methylene chloride/ethyl acetate (80-20 by volume)], collecting 25 cm3 fractions. Fractions 2 to 7 are combined and concentrated to dryness under reduced pressure (2.7 kPa) at 40° C. After recrystallization from acetonitrile, 0.12 g of N-(4-methoxyphenyl)-2-{2-[3-(3-methylphenyl)ureido]-N-phenylacetamido}acetamide melting at 194° C. is obtained.

Provenance & Evidence