Hydrazine hydrate (1:1) → HCID 14996908, compound

Participants

Reaction Steps

The procedure is analogous to that described in Example 23, but 3.1 g of N-ethyl-N-phenyl-2-(N-phenyl-2-phthalimidoacetamido)acetamide, 0.4 g of hydrazine hydrate and 0.54 g of 3-methylphenyl isocyanate are used as the starting material. The product obtained is purified by chromatography on 20 g of silica (0.065-0.200 mm) contained in a column 1.7 cm in diameter [eluent: methylene chloride], collecting 20 cm3 fractions. Fractions 10 to 23 are combined and concentrated to dryness under reduced pressure (2.7 kPa) at 40° C. After recrystallization from diethyl ether, 0.55 g of N-ethyl-N-phenyl-2-{2-[3-(3-methylphenyl)ureido]-N-phenylacetamido}acetamide melting at 158° C. is obtained.

Provenance & Evidence