m-Tolyl isocyanate → HCID 20097198, compound

Participants

Reaction Steps

The procedure is analogous to that described in Example 1, but 2.6 g of 2-(2-amino-N-phenylacetamido)-N-(4-fluorophenyl)-N-methylacetamide and 1.1 g of 3-methylphenyl isocyanate are used as the starting material. The crude product obtained is purified by chromatography on 60 g of silica (0.065-0.200 mm) contained in a column 2.0 cm in diameter [eluent: ethyl acetate/cyclohexane (50-50 by volume)], collecting 30 cm3 fractions. Fractions 6 to 10 are combined and concentrated to dryness under reduced pressure (2.7 kPa) at 40° C. After recrystallization from ethyl acetate, 1.8 g of N-(4-fluorophenyl)-N-methyl-2-{2-[3-(3-methylphenyl)ureido]-N-phenylacetamido}acetamide melting at 135° C is obtained.

Provenance & Evidence