HCID 14996934, compound → HCID 14996996, compound

HRID 1769715Notes

Reaction equation

HRID 1769715 reaction equation
[OH:1][CH:2]([C:4]1[CH:5]=[C:6]([NH:10][C:11](=[O:34])[NH:12][CH2:13][C:14]([N:16]([CH2:23][C:24]([N:26]([CH3:33])[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[O:25])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:15])[CH:7]=[CH:8][CH:9]=1)[CH3:3]>[O-2].[O-2].[Mn+4]>[C:2]([C:4]1[CH:5]=[C:6]([NH:10][C:11](=[O:34])[NH:12][CH2:13][C:14]([N:16]([CH2:23][C:24]([N:26]([CH3:33])[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[O:25])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:15])[CH:7]=[CH:8][CH:9]=1)(=[O:1])[CH3:3]

Participants

3

Reactant 1

HCID 14996934HCID 14996934, compound

Product 1

HCID 14996996HCID 14996996, compoundYield 46.6%

Reagents, catalysts & solvents 1

HCID 178418406HCID 178418406, compoundCatalyst

Procedure

The procedure is analogous to that described in Example 84, but 1.4 g of (RS)-2-{2-{3-[3-(1-hydroxyethyl)phenyl]ureido}-N-phenylacetamido}-N-methyl-N-phenylacetamide and 4.7 g of manganese dioxide are used as the starting material. After recrystallization from ethyl acetate, 0.65 g of 2-{2-[3-(3-acetylphenyl)ureido]-N-phenylacetamido}-N-methyl-N-phenylacetamide melting at 170° C is obtained.

Workup

  1. customAfter recrystallization from ethyl acetate

Sources & evidence

ORD record
ord-1b59734aa0944300879a5948a07dd661
Source dataset
uspto-grants-1995_01
Patent number
US05382590

Reaction notes

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