Pyridine → HCID 14997002, compound

Participants

Reaction Steps

0.18 g of pyridine and then 0.17 g of hydroxylamine hydrochloride in solution in 3 cm3 of water are added to a solution of 1 g of 2-{2-[3-(3-formylphenyl)ureido]-N-phenylacetamido}-N-methyl-N-phenylacetamide in 6 cm3 of methanol. The mixture is heated under reflux for 3 hours. After cooling, the insoluble product is separated off by filtration, washed with 3 times 3 cm3 of water and air-dried. After recrystallization from a dimethylformamide/water mixture (50/50 by volume), 0.5 g of (E)-2-{2-[3-(3-hydroxyiminomethylphenyl)ureido]-N-phenylacetamido}-N-methyl-N-phenylacetamide melting at 219° C is obtained.

Provenance & Evidence