m-Tolyl isocyanate → HCID 15670969, compound

Participants

Reaction Steps

Following a procedure analogous to that described in Example 106, but using 1.8 g of (RS)-2-amino-N-[2-(3-(N,N-diethylcarbamoyl)piperidino)-2-oxoethyl]-N-phenylacetamide and 0.64 g of 3-methylphenyl isocyanate as the starting material, 0.92 g of (RS)-N-[2-(3-(N,N-diethylcarbamoyl)piperidino)-2-oxoethyl]-2-[3-(3-methylphenyl)ureido]-N-phenyl acetamide melting at 156° C is obtained after recrystallization from an ethyl acetate/diisopropyl ether mixture (50/50 by volume).

Provenance & Evidence