Amantadine → HCID 20097383, compound

HRID 1769803Notes

Reaction equation

HRID 1769803 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[C:16]([CH2:26][CH2:27][CH2:28]C2C=CC=CC=2)=[C:17]([CH3:25])C=[CH:19][C:20]=1S([O-])(=O)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:35][C:36]12[CH2:45][CH:40]3[CH2:41][CH:42]([CH2:44][CH:38]([CH2:39]3)[CH2:37]1)[CH2:43]2>C(#N)C>[C:36]12([NH:35][CH2:19][CH2:20][CH:15]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[O:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:16]3[CH:17]=[CH:25][CH:28]=[CH:27][CH:26]=3)[CH2:37][CH:38]3[CH2:44][CH:42]([CH2:41][CH:40]([CH2:39]3)[CH2:45]1)[CH2:43]2

Participants

4

Reactant 2

HCID 2130AmantadineHCID 131718834HCID 131718834, compound

Product 1

HCID 20097383HCID 20097383, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

This compound was similarly prepared from the toyslate (XXIX) of Example 4d) and 1-aminoadamantane. It was used as start material in Example 7q). The hydrochloridesemihydrate was prepared in acetonitrile and melted at 225° C.

Sources & evidence

ORD record
ord-2898fb0a2c1445798bd0f4cab0abdc38
Source dataset
uspto-grants-1995_01
Patent number
US05382600

Reaction notes

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