Chlorine → HCID 20097342, compound

HRID 1769806Notes

Reaction equation

HRID 1769806 reaction equation
[Cl:1]Cl.[CH3:3][N:4]([CH2:9][CH2:10][CH:11]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[OH:24])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:5]([CH3:8])([CH3:7])[CH3:6]>C(O)(=O)C>[CH3:3][N:4]([CH2:9][CH2:10][CH:11]([C:18]1[CH:23]=[C:22]([Cl:1])[CH:21]=[CH:20][C:19]=1[OH:24])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:5]([CH3:8])([CH3:6])[CH3:7]

Participants

4

Reactant 2

HCID 24526ChlorineHCID 20097285HCID 20097285, compound

Product 1

HCID 20097342HCID 20097342, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

A solution of chlorine (7,1 g, 0,10 mol) in acetic acid (500 ml) is added dropwise to a stirred solution of N-methyl-N-tert.butyl-3-(2-hydroxyphenyl)-3 -phenylpropylamine (29.7 g. 0.10 mol) in acetic acid (200 ml) with stirring. After 2 h the solvent is distilled off under reduced pressure and the crude hydrochloride left is recrystallized from 2-propanol. Melting point 260° C.

Workup

  1. distillationAfter 2 h the solvent is distilled off under reduced pressure
  2. waitthe crude hydrochloride left
  3. customis recrystallized from 2-propanol

Sources & evidence

ORD record
ord-e7824d5dcf18442dac257932d4ce9f37
Source dataset
uspto-grants-1995_01
Patent number
US05382600

Reaction notes

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