Ammonia → 1-Nitro-4-phenoxybenzene

HRID 1769830Notes

Reaction equation

HRID 1769830 reaction equation
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].N.[N+:11]([C:14]1[CH:19]=[CH:18][C:17](Cl)=[CH:16][CH:15]=1)([O-:13])=[O:12]>>[CH:4]1[CH:5]=[CH:6][C:1]([O:7][C:17]2[CH:18]=[CH:19][C:14]([N+:11]([O-:13])=[O:12])=[CH:15][CH:16]=2)=[CH:2][CH:3]=1

Participants

5

Reactant 4

HCID 222AmmoniaHCID 996PhenolHCID 74741-Chloro-4-nitrobenzeneHCID 14798Sodium Hydroxide

Product 1

HCID 121101-Nitro-4-phenoxybenzene

Procedure

A steel autoclave was filled with 94 g (1 mole) of phenol and 40 g of sodium hydroxide pellets (1 mole), furthermore after sealing the autoclave 150 g of ammonia were injected. At 70° C., 157.5 g (1 mole) of p-nitrochlorobenzene were pumped into the autoclave as a liquid over a period of one hour; the mixture was stirred for a further 10 hours. After the pressure vessel was let town and the product obtained was washed with water, the 4-nitrodiphenyl ether was isolated at a more than 99% purity (by gas chromatography).

Workup

  1. customthe product obtained
  2. washwas washed with water

Sources & evidence

ORD record
ord-7f97711101be481aa9554777f85e4a5e
Source dataset
uspto-grants-1995_01
Patent number
US05382686

Reaction notes

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