Dimethylformamide → HCID 20095263, compound

Participants

Reaction Steps

0.70 g (0.0019 mol) of 4-(4-fluorophenyl)-2-(4,6-dimethoxypyrimidin-2-ylthio)nicotinic acid and 0.50 g (0.0036 mol) of potassium carbonate were weighed, and 10 ml of dimethylformamide was added thereto. The mixture was then stirred at room temperature for 1 hour. Thereafter, 0.34 g (0.0022 mol) of chloromethyl pivalate was further added to the resultant mixture, and the mixture was stirred at room temperature for 2 hours. The mixture was then poured into water, and was extracted with 50 ml of ethyl acetate. After washing with water and a saturated sodium chloride aqueous solution, it was dried with anhydrous sodium sulfate. After filtration, the solvent was distilled off, and the residue was purified by silica gel chromatography (developing solvent: ethyl acetate/hexane=1/4) to obtain 0.81 g of a yellowish thick syrup-like aimed product.

Provenance & Evidence