反应详情

温度

80 °C

50.0 g (0.15 mol) of methyl 2-bromo-4-(4-chlorophenyl)nicotinate was weighed, and 300 ml of dimethylsulfoxide and 60 ml of 30% sodium hydroxide aqueous solution were added thereto and the mixture was stirred at 80° C. for 3 hours. The mixture was then poured into water and was washed with 300 ml of ethyl acetate. Thereafter, the aqueous layer was acidified with 10% HCl aqueous solution to precipitate a crystal, which was then filtrated out. The crystal thus precipitated was washed with water and isopropyl ether, and was dried to obtain 41.0 g of a white crystal of the aimed product.

1. washwas washed with 300 ml of ethyl acetate
2. customto precipitate a crystal, which
3. filtrationwas then filtrated out
4. customThe crystal thus precipitated
5. washwas washed with water and isopropyl ether
6. customwas dried