反应详情

To a solution of ethyl 2-(3-methoxy-2,4,5-triflurobenzoyl)-3-ethoxyacrylate (590 mg, 1.8 mmol) in methylene chloride (15 mL) at 0° C. was added a solution of cyclopropylamine (114 mg, 1.98 mmol, 1.2 equiv) in methylene chloride (5 mL). The reaction mixture was warmed to room temperature and allowed to stir for 2 hours. The solvent was removed in vacuo and the crude concentrate was purified by flash chromatography on silica gel (methylene chloride/ethyl acetate 50:1 v/v) to provide 438 mg, 62% yield over two steps, of a viscous yellow oil.

1. customThe solvent was removed in vacuo
2. concentrationthe crude concentrate
3. customwas purified by flash chromatography on silica gel (methylene chloride/ethyl acetate 50:1 v/v)
4. customto provide 438 mg, 62% yield over two steps