HCID 15231089, compound → HCID 15780057, compound

HRID 1770140Notes

Reaction equation

[CH3:1][O:2]CC1NC(=O)C2C(=CC=CC=2)N=1.[N+:15]([C:18]1[CH:19]=[C:20]2[C:25](=[CH:26][CH:27]=1)[N:24]=[C:23]([CH2:28]CC)[N:22]([CH2:31][C:32]1[CH:37]=[CH:36][C:35]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=3[C:44]3[N:48]([C:49]([C:62]4[CH:67]=[CH:66][CH:65]=[CH:64][CH:63]=4)([C:56]4[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=4)[C:50]4[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=4)[N:47]=[N:46][N:45]=3)=[CH:34][CH:33]=1)[C:21]2=[O:68])([O-:17])=[O:16]>>[CH3:1][O:2][CH2:28][C:23]1[N:22]([CH2:31][C:32]2[CH:37]=[CH:36][C:35]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=3[C:44]3[N:48]([C:49]([C:50]4[CH:51]=[CH:52][CH:53]=[CH:54][CH:55]=4)([C:62]4[CH:67]=[CH:66][CH:65]=[CH:64][CH:63]=4)[C:56]4[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=4)[N:47]=[N:46][N:45]=3)=[CH:34][CH:33]=2)[C:21](=[O:68])[C:20]2[C:25](=[CH:26][CH:27]=[C:18]([N+:15]([O-:17])=[O:16])[CH:19]=2)[N:24]=1

Participants

Reactant 2

HCID 15231089HCID 15231089, compound

HCID 135471313HCID 135471313, compound

Product 1

HCID 15780057HCID 15780057, compound

Procedure

2-methoxymethylquinazolin-4(3H)-one was alkylated in the same manner as described above for 6-nitro-2-n-propyl-3-[(2'-(N-triphenylmethyl-tetrazol-5-yl)-biphen-4-yl)-methyl]-quinazolin-4(3H)-one to give the title compound. 200 MHz-1H-NMR (CDCl3):3.43 (s, 3H), 4.36 (s, 2H), 5.46 (bs, 2H), 6.90 (m, 6H), 7.00 (d, 2H, J=8.2 Hz), 7.12 (d, 2H, J=8.2 H ), 7.19-7.38 (m, 10H), 7.48 (m, 2H), 7.84(d, 1H, J=8.9 Hz), 7.92 (m, 1H), 8.56 (dd, 1H, J=2.7, 9.01 Hz), 9.20 (d, 1H, J=2.6 Hz).

Sources & evidence

ORD record: ord-cfc235b6a9514913a5ee946982e536c9
Source dataset: uspto-grants-1995_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05385894

Reaction notes

Loading…