反应详情

0.30 g (1.09 mM) of 2-octylindan-5-boronic acid, 0.37 g (0.95 mM) of 5-decyloxy-2-(4-bromophenyl)pyrimidine, 1.8 ml of ethanol, 2.5 ml of benzene, 1.5 ml of 2M-sodium carbonate aqueous solution and 0.05 g of tetrakis (triphenylphosphine) palladium (O) were mixed and heat-refluxed for 4 hours under stirring. After the reaction, the reaction mixture was poured into ice water to precipitate a crystal. The crystal was recovered by filtration under reduced pressure and dissolved in toluene, followed by drying with anhydrous sodium sulfate. Then, the sodium sulfate was removed from the mixture and the resultant mixture was evaporated to obtain a residue. The residue was purified by silica gel column chromatography (eluent: toluene/ethyl acetate=100/1) and recrystallized two times from a mixture solvent (toluene/acetone) to obtain 0.42 g of 2-octyl-5-[4-(5-decyloxypyrimidine-2-yl)phenyl]indan (Yield: 82.1%). ##STR279##

1. temperatureheat-refluxed for 4 hours
2. customAfter the reaction
3. customto precipitate a crystal
4. filtrationThe crystal was recovered by filtration under reduced pressure
5. dissolutiondissolved in toluene
6. dry with materialby drying with anhydrous sodium sulfate
7. customThen, the sodium sulfate was removed from the mixture
8. customthe resultant mixture was evaporated
9. customto obtain a residue
10. customThe residue was purified by silica gel column chromatography (eluent: toluene/ethyl acetate=100/1)
11. customrecrystallized two times from a mixture solvent (toluene/acetone)