反应详情

0.41 g (1.50 mM) of 2-octylindan-5-boronic acid, 0.45 g (1.30 mM) of 2-octyl-5-(4-bromophenyl)pyrimidine, 2.2 ml of ethanol, 4.2 ml of benzene, 2.1 ml of 2M-sodium carbonate aqueous solution and 0.07 g of tetrakis (triphenylphosphine) palladium (O) were mixed and heat-refluxed for 200 minutes under stirring. After the reaction, the reaction mixture was poured into ice water and subjected to extraction with ethyl acetate, followed by washing with saturated common salt aqueous solution. The organic layer was dried with anhydrous sodium sulfate. Then, the sodium sulfate was removed from the organic layer and the resultant organic layer was evaporated to obtain a residue. The residue was purified by silica gel column chromatography (eluent: toluene/ethyl acetate=100/1) and recrystallized from a mixture solvent (toluene/acetone) and ethyl acetate to obtain 0.46 g of 2-octyl-5-[4-(2-octylpyrimidine-5-yl)phenyl]indan (Yield: 71.5%). ##STR301##

1. temperatureheat-refluxed for 200 minutes
2. customAfter the reaction
3. extractionsubjected to extraction with ethyl acetate
4. washby washing with saturated common salt aqueous solution
5. dry with materialThe organic layer was dried with anhydrous sodium sulfate
6. customThen, the sodium sulfate was removed from the organic layer
7. customthe resultant organic layer was evaporated
8. customto obtain a residue
9. customThe residue was purified by silica gel column chromatography (eluent: toluene/ethyl acetate=100/1)
10. customrecrystallized from a mixture solvent (toluene/acetone) and ethyl acetate