Ethanol → HCID 20095031, compound

Participants

Reaction Steps

1.00 g (4.06 mM) of 2-hexylindan-5-boronic acid, 0.64 g (4.04 mM) of 2-chloro-5-nitropyrimidine, 5 ml of ethanol, 6 ml of benzene, 5.6 ml of 2M-sodium carbonate aqueous solution and 0.24 g of tetrakis (triphenylphosphine) palladium (O) were mixed and heat-refluxed for 30 minutes under stirring. After the reaction, the reaction mixture was subjected to filtration under reduced pressure to obtain an insoluble matter. The insoluble matter was washed with ethyl acetate and recrystallized from acetone to obtain 1.02 g of 2-hexyl-5-(5-nitropyridine-2-yl)indan (Yield: 77.4%).

Provenance & Evidence