反应详情

1.78 g (6.5 mM) of 2-octylindan-5-boronic acid, 2.0 g (6.5 mM) of 4-(trans-4-pentylcyclohexy)phenyl bromide, 4 ml of ethanol, 8 ml of benzene, 8 ml of 2M-sodium carbonate aqueous solution and 0.24 g of tetrakis (triphenylphosphine) palladium (O) were mixed and heat-refluxed for 5 hours under stirring. After the reaction, the reaction mixture was poured into ice water, followed by extraction with toluene, washing with water and drying with anhydrous sodium sulfate. Then, the sodium sulfate was removed from the mixture and the resultant mixture was evaporated to obtain a residue. The residue was purified by silica gel column chromatography (eluent: hexane) and recrystallized from a mixture solvent (toluene/methanol) to obtain 1.52 g of 2-octyl-5-[4-(trans-4-pentylcyclohexyl)phenyl]indan (Yield: 51.0%). ##STR310##

1. temperatureheat-refluxed for 5 hours
2. customAfter the reaction
3. extractionfollowed by extraction with toluene
4. washwashing with water
5. dry with materialdrying with anhydrous sodium sulfate
6. customThen, the sodium sulfate was removed from the mixture
7. customthe resultant mixture was evaporated
8. customto obtain a residue
9. customThe residue was purified by silica gel column chromatography (eluent: hexane)
10. customrecrystallized from a mixture solvent (toluene/methanol)