Ethanol → HCID 20095037, compound

Participants

Reaction Steps

1.0 g (4.3 mM) of 2-pentylindan-5-boronic acid, 0.42 g (2.16 mM) of 5-bromo-2-chloropyrimidine, 4 ml of ethanol, 6 ml of benzene, 6 ml of 2M-sodium carbonate aqueous solution and 0.18 g of tetrakis (triphenylphosphine)palladium (O) were mixed and heat-refluxed for 2 hours under stirring. After the reaction, the reaction mixture was poured into ice water to precipitate a crystal. The crystal was recovered by filtration under reduced pressure and purified by silica gel column chromatography (eluent: toluene) and recrystallized from a mixture solvent (toluene/methanol) to obtain 0.63 g (1.40 mM) of 2,5-bis(2-pentylindan-5-yl)pyrimidine (Yield: 65%). ##STR328##

Provenance & Evidence