HCID 86748425, compound → HCID 86748424, compound

HRID 1770197Notes

Reaction equation

HRID 1770197 reaction equation
C([NH:20][C:21]1[S:22][CH:23]=[C:24]([C:26](=[N:55][O:56][CH3:57])[C:27]([NH:29][C@@H:30]2[C:37](=[O:38])[N:36]3[C@@H:31]2[CH2:32][S:33][C:34](/[CH:46]=[CH:47]/[CH2:48][N:49]2[CH:53]=[CH:52][N:51]=[C:50]2[CH3:54])=[C:35]3[C:39]([O:41]C(C)(C)C)=[O:40])=[O:28])[N:25]=1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>C(O)=O>[NH2:20][C:21]1[S:22][CH:23]=[C:24]([C:26](=[N:55][O:56][CH3:57])[C:27]([NH:29][C@@H:30]2[C:37](=[O:38])[N:36]3[C@@H:31]2[CH2:32][S:33][C:34](/[CH:46]=[CH:47]/[CH2:48][N:49]2[CH:53]=[CH:52][N:51]=[C:50]2[CH3:54])=[C:35]3[C:39]([OH:41])=[O:40])=[O:28])[N:25]=1

Participants

3

Reactant 1

HCID 86748425HCID 86748425, compound

Product 1

HCID 86748424HCID 86748424, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

80.5 mg of the product of Step A and 1 ml of 66% formic acid were heated for 3 hours at 60°-65° C. and then was evaporated to dryness under reduced pressure. The residue was taken up twice consecutively with 5 ml of water, then evaporated to dryness. The residue was taken up in 7 ml of ether, stirred for half-an-hour, then separated to obtain 41.5 mg of syn isomer of (6S,7S) 7-[2-(2-aminothiazol-4-yl)-2-methoxyimino-acetamido]-3-[3-(2-methyl-1H-imidazol-1-yl)1-(E)-propenyl]-8-oxo-4-thia-1-azabicyclo[4,2,0]oct-2-en-2-carboxylic acid

Workup

  1. customwas evaporated to dryness under reduced pressure
  2. customevaporated to dryness
  3. customseparated

Sources & evidence

ORD record
ord-c9dde033ddb74079b26bd6c4639821ce
Source dataset
uspto-grants-1995_01
Patent number
US05385897

Reaction notes

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